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The route between Newark (EWR) and San Francisco (SFO) is one of the finest examples of a transcontinental business route in America that connects two major financial and technological centers of the nation. If you are traveling from Wall Street to Silicon Valley, pitching your start-up, or viewing the Golden Gate Bridge, this route experiences high year-round demand from business travelers and has an entirely different pricing pattern compared to a standard leisure route. There is a distance of 2,565 air miles between the cities, while non-stop flight duration will be approximately 6 hours and 5 minutes to 6 hours and 40 minutes westbound into the prevailing wind, and about 5 hours and 30 minutes eastbound. That is a five-day journey transformed into one day.

Since it's a highly professional route, the following tips will help you book a cheaper ticket in a much easier way:

Since this is mainly a business route, its seasonality is driven by the corporate calendar and the Bay Area’s weather rather than school breaks.
Prices drop slightly after the New Year corporate travel freeze, but will increase as the month goes on with increased business travel at the various conferences that take place during this time of year.
This period sees a fair amount of corporate travel with prices being relatively constant. Fares do rise marginally during tech conferences; therefore, it makes sense to verify the dates on the calendar before booking tickets.
Some of the best value periods in the year. Corporate travel remains fairly consistent but not at its peak. Shoulder season offers some of the best prices until summer.
Summer vacationers, aside from the steady corporate travel, make this one of the busiest months even though San Francisco sees fairly cool summers. Highest prices are in July.
This is peak season for corporate trips in the area, with major conventions contributing to crowded planes. The ticket prices might be even higher during this season compared to summer due to fewer leisure travelers. Do not automatically assume that September-October is cheaper on this route since it is off-season.
After the end of the conference season, fares become lower except for the time during Thanksgiving week itself. Booking 5-7 weeks in advance will be beneficial during this season.
There is a significant reduction in corporate travel after the middle of the month, leading to fares becoming quite low between mid-December and pre-Christmas days, and rising sharply around Christmas and New Year's days as expected.